Abstract
Neuroscience Each memory is stored in a distinct memory trace in the brain, in a specific population of neurons called engram cells. How does the brain store and define the identity of a specific memory when two memories interact and are encoded in a shared engram? Abdou et al. used optogenetic reactivation coupled with manipulations of long-term potentiation to analyze engrams that share neurons in the lateral amygdala (see the Perspective by Ramirez). Synapse-specific plasticity guaranteed the storage and the identity of individual memories in a shared engram. Moreover, synaptic plasticity between specific engram assemblies was necessary and sufficient for memory engram formation. Science , this issue p. [1227][1]; see also p. [1182][2] [1]: /lookup/doi/10.1126/science.aat3810 [2]: /lookup/doi/10.1126/science.aau0043
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