Abstract
Meeting Abstracts1 May 1971Diseases of Uric Acid Metabolism.J. Edwin Seegmiller, M.D.J. Edwin Seegmiller, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-844_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMost of the clinical manifestations of gouty arthritis can be directly related to the limited solubility of uric acid and its salts in biological fluids. Deposition of crystals of monosodium urate in and about the joints, tendons, and renal parenchyma gives rise to the acute attacks of gout and joint destruction and contributes to the renal damage of this disease. Deposits of free uric acid at the lower pH encountered in the urinary tract also contribute to renal damage and a rate of renal calculus formation around a thousand times that of the general population. The underlying hyperuricemia results from... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: La Jolla, Calif. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 844-844KeywordsArthritisGoutKidney stonesRenal diseasesSaltsTendonsUric acid Issue Published: 1 May 1971 PDF downloadLoading ...
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