Abstract
Reprogrammed cellular metabolism is a common characteristic observed in various cancers. Yet it remains poorly understood whether metabolic changes directly regulate development and progression in hematologic malignancies. Here we show that BCAT1, a cytosolic aminotransferase for the branched-chain amino acids (BCAAs), is aberrantly activated and functionally required for chronic myeloid leukemia (CML). BCAT1 is up-regulated during CML progression and mediates BCAA production in leukemia cells by the transamination of the branched-chain keto acids.
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