Abstract
In reply to the letter from Hallett et al. (1), we would like to clarify some subtleties. The unexpected finding of our paper (2) was that degeneration of the striatal component of grafts resembled, in many ways, the neural degeneration in the striatum of patients with Huntington's disease (HD). These similarities include that (i) grafted projection neurons degenerated preferentially in comparison to interneurons, which recapitulates the pattern of neural degeneration in HD; (ii) cells degenerated at least in part via apoptotic mechanisms; (iii) cells had a markedly degenerated appearance in comparison with our earlier report at 18 months after transplantation in a patient with HD using identical techniques; …
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