Abstract
ObjectiveTo report the incidence rate ratios (IRR) of acute myocardial infarctions (AMI) and cerebrovascular events (CVE) in incident SLE cases from a defined population. To study the risk factors for...
Highlights
SLE is an autoimmune disorder with multiple organ manifestations
The same bimodal pattern was described in the 1970s for mortality, with active disease or infections involved with shorter disease duration and acute myocardial infarctions (AMI) and possibly cerebrovascular events (CVE) after longer disease duration.[1 2]
Patient and population demographic data and potential risk factors for cardiovascular disease (CVD) present at diagnosis are given in tables 1a and b
Summary
Morbidity in early disease is characterised by active inflammatory processes, while later morbidity is primarily as a consequence of long-s tanding inflammation or treatment with corticosteroids leading to organ damage, especially cardiovascular disease (CVD). Regarding CVD in SLE the most striking finding has been the relatively higher frequency of this manifestation in women before menopause, a group in the general population which often is considered to be protected.[5 8 14]
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