Disease burden of age-related macular degeneration in China from 1990 to 2019: findings from the global burden of disease study.

Yichi Zhang,Guangming Jin,Danying Zheng,Min Fan,Aiming Chen,Minjie Zou,Zhenlan Yang

doi:10.7189/jogh.11.08009

Abstract

BackgroundTo evaluate the disease burden of age–related macular degeneration (AMD) in terms of disability-adjusted life years (DALY) in China from 1990 to 2019.MethodsPrevalence of blindness and vision loss due to AMD and DALY number, rate, and age-standardized rates of AMD were collected from the Global Burden of Disease Study 2019 database. The characters of variables were analyzed between China and its neighboring countries.ResultsFrom 1990 to 2019, the all-age number and rate for AMD prevalence and DALYs increased significantly in China, while the age standardized DALYs rate in 2019 showed a decrease of 3.63% compared with that in 1990. Females were found to have a higher prevalence and DALYs than males. The 65-69 age group had the highest AMD DALYs number, while the DALYs rate showed a positive association with age. In 2019, when compared to neighboring countries, the age standardized prevalence rate of AMD in China was ranked second after Pakistan, while the age standardized DALYs rate ranked second after Pakistan and India.ConclusionsDespite a small decrease in age standardized DALYs rate in China in the past three decades, the disease burden of AMD is still considerable and much higher compared to neighboring developed countries. Optimizing health services allocation is needed to further reduce this burden.

Highlights

To evaluate the disease burden of age–related macular degeneration (AMD) in terms of disability-adjusted life years (DALY) in China from 1990 to 2019
Despite a small decrease in age standardized DALYs rate in China in the past three decades, the disease burden of AMD is still considerable and much higher compared to neighboring developed countries
With China having the largest population in the world with a growing aging population, [9] it was estimated that China had the greatest number of people with AMD in 2019

Summary

Methods

Prevalence of blindness and vision loss due to AMD and DALY number, rate, and age-standardized rates of AMD were collected from the Global Burden of Disease Study 2019 database. AMD prevalence and disease burden were extracted from the GBD 2019 study in the Global Health Data Exchange (GHDx, http://ghdx.healthdata.org/gbd-results-tool). DALYs attributable to AMD were defined as the sum of the years lived with disability (YLD) and the years of life lost (YLL), and was calculated by the following formula: DALY number = (Number of deaths × Standard life expectancy at age of death in years) + (Number of prevalent cases × Disability weight). The DALY rate was calculated by adjusting for population size as the number of cases per 100 000 population, while the age-standardized DALY rate was further adjusted for age structure

Results

Discussion

Conclusion