Disease and thermal acclimation in a more variable and unpredictable climate

Abstract

Few studies have considered the effects of changes in climatic variability on disease incidence. Now research based on laboratory experiments and field data from Latin America shows that frog susceptibility to the pathogenic chytrid fungus is influenced by temperature variation and predictability through effects on host and parasite acclimation. Global climate change is shifting the distribution of infectious diseases of humans and wildlife with potential adverse consequences for disease control1,2,3,4. As well as increasing mean temperatures, climate change is expected to increase climate variability5,6, making climate less predictable. However, few empirical or theoretical studies have considered the effects of climate variability or predictability on disease, despite it being likely that hosts and parasites will have differential responses to climatic shifts6,7. Here we present a theoretical framework for how temperature variation and its predictability influence disease risk by affecting host and parasite acclimation responses. Laboratory experiments conducted in 80 independent incubators, and field data on disease-associated frog declines in Latin America6, support the framework and provide evidence that unpredictable temperature fluctuations, on both monthly and diurnal timescales, decrease frog resistance to the pathogenic chytrid fungus Batrachochytrium dendrobatidis. Furthermore, the pattern of temperature-dependent growth of the fungus on frogs was opposite to the pattern of growth in culture, emphasizing the importance of accounting for the host–parasite interaction when predicting climate-dependent disease dynamics. If similar acclimation responses influence other host–parasite systems, as seems likely, then present models, which generally ignore small-scale temporal variability in climate7, might provide poor predictions for climate effects on disease.