Abstract
Systemic lupus erythematosus (SLE) is a heterogeneous collection of difficult-to-catalogue symptoms, physical findings, serological markers, and laboratory abnormalities manifested in varying degrees over time. In 1984, Urowitz et al1 proposed the first disease activity index—the LACC, or lupus activity criteria count. It took another 10 years to evolve consensus-derived activity indices, of which the British Isles Lupus Assessment Group (BILAG) and SLE Disease Activity Index (SLEDAI) stood out as being more useful and relevant than others.
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