Abstract
Answer: Amiodarone is an iodine containing benzofuran derivative that initially was developed as an antianginal drug but is used essentially for its antiarrhythmic effects. Classified as a potent class III antiarrhythmic agent, amiodarone is unique in that it encompasses properties from all four Vaughan Williams classes. At the cellular level it inhibits the cardiac sodium, calcium, and potassium channels and possesses antiadrenergic properties. This translates into its electrophysiologic effects that include lengthening of action potential duration resulting in prolongation of refractory periods of both the atria and ventricles, and reduction in sinus node and atrial automaticity and AV nodal conduction. Amiodarone does not possess negative inotropic effects and, therefore, can be used with greater safety in patients with congestive heart failure.
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