Abstract
Nerve regeneration is a process of self-recovery after nerve injury. Nerve regeneration is more difficult in the central nervous system (CNS) than in the peripheral nervous system (PNS). So far, there are few cases of CNS cure. The difficulty of CNS regeneration brings great loss to patients and society. In recent years, scientific research has found that damage to the CNS is caused by mechanisms that hinder its regeneration. This review has provided a comprehensive summary of recent studies on the inhibitory mechanism of glial scar, which are the main factors affecting axonal regeneration in the CNS, and deeply discussed the mechanism of a series of factors related to glial scar, such as CSPGs, Nogo family proteins, NgR1, LINGO-1 and p75, on the production of glial scar. After this, the idea of their ability to study the regeneration of the CNS after injury was analyzed, and the new technology of anti-inhibition of CNS regeneration therapy was looked forward.
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