Abstract
Dr. Terry and Ms. Ousley describe the 6-month and 12-month data for the first U.S. clinical trial of a new surgical approach for the correction of corneal edema secondary to endothelial cell failure. Corneal edema from endothelial cell dysfunction, as in Fuchs’ dystrophy, aphakic bullous keratopathy, and pseudophakic bullous keratopathy, is the leading cause for penetrating keratoplasty in this country. Penetrating keratoplasty (PK) is still the gold standard for endothelial replacement in treating these diseases. Recently, new surgical techniques have been devised to replace only the posterior stroma and endothelium in a lamellar fashion. These procedures include: deep lamellar endothelial keratoplasty (DLEK), as described by Dr. Terry; endokeratoplasty, as described by Drs. Bussin and Arffa; endothelial lamellar keratoplasty, as described by Dr. Culbertson; and microkeratome-assisted posterior keratoplasty, as described by Dr. Azar.
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