Discussion Addendum for: Preparation of (R,R)‐1,2:4,5‐Diepoxypentane

Abstract

AbstractEnantiopure 1,2:4,5‐diepoxypentanes and their dichlorodiol precursors have proven to be useful intermediates in the synthesis of complex natural products. While these C2 symmetric bis‐electrophiles have most commonly been employed in the installation of anti‐1,3 diol motifs, they have also recently been leveraged in development of new methods and utilized in the synthesis of chiral building blocks. This addendum discusses these applications, as well as the use of these materials in the context of the total synthesis of complex natural products. It provides information on simultaneous and sequential double addition strategies in natural product synthesis. The addendum also discusses the P. R. Hanson's synthesis of chiral bicyclo[4.3.1]phosphate triester building blocks and J. Aube's extension through synthesis of valuable chiral building blocks.