Abstract
The present study was designed to assess the discriminative stimulus properties of cocaine in pigeons. Six pigeons were trained to discriminate IM injections of cocaine (2 mg/kg) from saline with responding maintained under a fixed-ratio 30 schedule of food delivery. Cocaine, d-amphetamine, and l-cathinone substituted completely for the training dose of cocaine in all pigeons. When nicotine (0.25-4.0 mg/kg), apomorphine (0.03-1.0 mg/kg), procaine (4-32 mg/kg), and lidocaine (4-16 mg/kg) were substituted, both partial substitutions and individual differences between pigeons were observed. Oxazepam (0.5-4.0 mg/kg) and pentobarbital (2-8 mg/kg) failed to substitute for the training dose of cocaine. Discriminative stimulus control by cocaine was greatest when the drug was administered 10-40 min prior to the session and the effects disappeared after 2 h. The substitution results indicate drug class specificity of the cocaine cue but, in addition, suggest its multidimensional nature.
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