Abstract
Although the AMPH and CATH cues have been studied extensively, inconsistent findings remain that need to be investigated. It is not known to what extent, if at all, AMPH and CATH cues differ and how they differ from the cocaine cue. The extent to which D1 and D2 receptor systems are coupled in AMPH DD assays requires further investigation. The inconsistent findings in substitution studies with nisoxetine need to be addressed in parametric studies in various species. Finally, the possibility that the AMPH cue may generate false positives in screening for drug abuse potential needs to be evaluated.
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