Abstract
Our previous studies have proved that preclinical Alzheimer's disease (AD) which including subjective cognitive decline (SCD) stage, can be distinguished from normal control (NC) by glucose-oxygen metabolism coupling at the voxel level, but whether the coupling at the network level worked has not been studied. Therefore, this study aimed to explore the coupling relationship between brain glucose metabolic connectivity network and oxygen functional connectivity network, and whether its feasibility as a biomarker to discriminate SCD from healthy control (HC). Resting-state functional magnetic resonance imaging (rs-fMRI) and glucose positron emission tomography (PET) based on hybrid PET/MRI scans were used to investigate metabolism-oxygen metabolism coupling in 56 SCD individuals and 54 HCs. Network coupling features were selected by logistic regression-recursive feature elimination (LR-RFE), and then a linear support vector machine (SVM) was used to distinguish SCD and HC by using 5-fold cross-validation. The classification average accuracy of network coupling had reached 76.36% with a standard deviation of 9.85% (with a sensitivity of 77.82%±15.13% and a specificity of 75.30%±15.15%). After receiver operating characteristic (ROC) analysis, the average area under curve (AUC) of network coupling was 0.788 (95% confidence interval [Formula: see text]). This study provided a new perspective for exploring network coupling. The proposed classification method highlighted the potential clinical application by combing glucose-oxygen metabolism coupling and machine learning in identifying SCD.
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More From: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
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