Abstract
Die Differenzierung von astrozytischen Hirntumorgraden kann durch direkte Lipidanalyse mittels Desorptions-Elektrosprayionisations-Massenspektrometrie (DESI-MS) erreicht werden. Charakteristische Lipidprofile sind mit der Tumormalignanz entsprechend den WHO-Graden II, III und IV assoziiert (siehe Bild).
Highlights
Amongst the Mass spectrometry (MS) imaging methods, the newer ambient ionization techniques allow the direct analysis of samples in the open atmosphere.[4]
The sphingo and glycerophospholipid compositions of astrocytoma tumor samples were investigated, and distinct lipid profiles concordant with World Health Organization (WHO) grade were observed. These results show that differentiation of grade within this type of human brain cancer can be achieved by direct desorption electrospray ionization mass spectrometry (DESI-MS) analysis of tissue with the lipid constituents providing the needed information
While the lipid profiles observed for grade II and grade IV astrocytomas are distinct, the negative ion mode mass spectrum obtained from sample G4, a case of anaplastic astrocytoma (WHO grade III), Figure 1b, presents a transitional lipid composition, showing the presence of the sulfatide ions observed in the grade II sample, as well as an increased abundance of glycerophosphoserine peaks characteristic of the GBM lipid profile
Summary
Graham Cooks*[Prof.] Department of Chemistry and Center for Analytical Instrumentation and Development Purdue University, West Lafayette, IN 47907 (USA) Dr Nathalie Y.R. Agar* Department of Neurosurgery, Department of Radiology, and Department of Medical Oncology Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School Boston, MA 02115, (USA)
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