Discriminant models of the possibilities of occurrence and features of the course of benign nevi in men depending on the characteristics of dermatoscopic parameters

Abstract

Human skin is the first barrier to protect the body from external factors. Combinations of certain external and internal (genetically determined) factors can lead to cancer of this organ. One of such pathologies is nevi – still little studied disease. At the same time, modern medicine is interested in inventing mechanisms to predict their occurrence and course. The purpose of the study is to build and analyze discriminant models of the possibility of benign nevi in Ukrainian men depending on the characteristics of dermatoscopic parameters. Ukrainian men aged 22 to 35 years, patients with melanocyte benign simple nevi (n=34), melanocyte benign dysplastic nevi (n=27), melanocyte benign congenital nevi (n=14) and non-melanocyte benign nevi (n=17) get dermatoscopic examination. The possibility of benign nevi occurrence depending on the characteristics of dermatoscopic parameters was carried out using discriminant analysis in the licensed statistical package “Statistica 5.5”. With the help of discriminant analysis, reliable models of the possibility of occurrence of benign nevi depending on the characteristics of dermatoscopic parameters are built. It was found that among patients with melanocyte benign simple, dysplastic, congenital and non-melanocyte benign nevi, a reliable interpretation of the obtained classification indicators is possible (discriminant function covers 70.7 % of cases; statistics Wilks' Lambda=0.185; p<0.001). The models include the general dermatoscopic index, the dermatoscopic criterion “Asymmetry” according to the ABCD system, the number of nevi on the body more than 1 cm and the dermatoscopic criterion “Color” according to the ABCD system. Moreover, the general dermatoscopic index and the dermatoscopic criterion “Asymmetry” according to the ABCD system make the greatest contribution to discrimination between Ukrainian men with benign nevi.