Abstract
Acute cerebral hypoperfusion is experienced on head‐to‐foot inertial force (+Gz). However, no report has been found about redistribution of blood flow inside the brain. Then we estimate blood flow (BF) and tissue‐oxygen (PO2) level responses to +Gz stress in the cortex and hippocampus. In 13 male Sprague‐Dawley rats were anesthetized with urethane, cortical and hippocampal blood flows or these PO2 levels were measured by a laser blood flow meter with the glass fiber prove or a PO2 monitor with the polarographic oxygen electrodes, respectively. +Gz stress of 3.0 G by a centrifuge decreased arterial pressure at a level of the brain to 39.3 ± 13.5 mmHg, cortical and hippocampal BF to 77.0 ± 17.2% and 66.6 ± 15.1 %, respectively (NS), and these PO2 to 77.8 ± 14.7 % and 58.9 ± 19.7 %, respectively (p<0.05). After +Gz exposure, PO2 returned significantly slower than BF in both of the hippocampus and the cortex. These results indicate that acute cerebral hypoperfusion may induce more ischemic damages in the hippocampus than the cortex.
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