Abstract
Objective:In the past, accurate diagnosis of lymphoma was challenging since there were multiple competing classification systems that caused confusion and debate. After establishment of the World Health Organization lymphoma classification, lymphomas still remain a diagnostic challenge among general pathologists. The purpose of this study was to examine whether the discordance among centers has declined over the years.Materials and Methods:All lymphoma or lymphoma-suspected specimens that had been sent to the Cerrahpaşa Faculty of Medicine between 2000 and 2013 for a second opinion were deemed eligible. To evaluate the change in the discrepancy rates over time we compared the rates of revision between 2000-2008 and 2009-2013.Results:A total of 1824 patients in two time periods met the inclusion criteria. The overall discordance rate was 45.6%. This rate showed significant variations between different histologic subtypes. Discordance rates also varied significantly over time and decreased from 51.3% in 2000-2008 to 38.7% in 2009-2013 (p<0.0001).Conclusion:The high discordance rate, especially in the second period, indicates the need for easily accessible hematopathology consultation centers.
Highlights
Accurate histologic diagnosis is the most crucial step for the appropriate management of patients with lymphoma
Materials and Methods: All lymphoma or lymphoma-suspected specimens that had been sent to the Cerrahpaşa Faculty of Medicine between 2000 and 2013 for a second opinion were deemed eligible
Lymphomas still remain a diagnostic challenge among general pathologists
Summary
Accurate histologic diagnosis is the most crucial step for the appropriate management of patients with lymphoma In the past this was challenging since there were numerous competing classification systems, which caused conflict and discussion [1,2]. Lymphomas still remain a diagnostic challenge among general pathologists The literature on this topic reveals that widely varying agreement values have been reported recently [6,7,8,9,10]. These studies encompassed short periods and/or assessed relatively small numbers of cases. We designed our study to investigate the situation in Turkey with many more cases to cover a longer period
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Schedule a callMore From: Turkish journal of haematology : official journal of Turkish Society of Haematology
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