Discovery of novel thiazolidinone-1,2,3-triazole hybrids with (D)-Limonene skeleton as anticancer agents: Design, synthesis and biological evaluation

Abstract

In the present study, a series of natural bioactive (D)-Limonene-based 1,2,3-triazole 14a-e hybrids were synthesized by copper (II)-catalyzed [3 + 2] cycloaddition reaction. Synthetic products are characterized by spectroscopic techniques (1H- and 13C NMR). Our objective is to evaluate the anticancer activity against human cancer cell lines HT-1080, A-549, MCF-7 and MDA-MB-231. Indeed, we found that the majority of 1,2,3-triazole hybrids 14a-e showed average cytotoxic activity towards all conquering cells tested with IC50 values between 13.03 ± 0.67 and 41.66 ± 1.98 μM, except in the case of 14d, which represents IC50 values 13.03 ± 0.67 μM and 15.98 ± 2.03 μM respectively against HT-1080 and A-549 cells.