Abstract
Oxidative stress and cellular excitotoxicity is inherent in the pathophysiology of an array of devastating human ailments. Natural products have played an important role in the treatment of a variety of human diseases and continue to drive the modern drug discovery and development process. The overall goal of this project is to design a novel neuroactivity assay to identify natural products capable of inducing neuroprotection against oxidative stress. This project will focus on a group of natural products, pseudopterosins, known for their potent biological activities with a novel mechanism of action. We hypothesize that these compounds may be of potential therapeutic benefit in protecting neurons and/or neural function both during and after episodes of excitotoxicity in disease states.
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