Discovery of human Hv1 channel peptide inhibitors

Abstract

Human proton channel (hHv1) is a voltage-gated ion channel, which plays an important role in immune and cancer cells such as proliferation, migration, and oxidative burst. The structure of this protein differs from other voltage-gated ion channels as it has two voltage-sensing domains without a conventional ion-conducting pore. This dissemblance could answer for the lack of selective hHv1 inhibitors. The aim of this project was to find a selective peptide blocker for hHv1, which could provide a sufficient treatment for cancer patients in the future.