Abstract
E-mail: skahn@incheon.ac.krReceived June 27, 2014, Accepted July 11, 2014Key Words : Focal adhesion kinase 1, Kinase inhibitor, Anticancer drug, Quantum mechanical calculations,Structure-based drug designFocal adhesion kinase (FAK) is a 125-kDa non-receptorprotein tyrosine kinase that associates with both integrinreceptors and some growth factor receptor tyrosine kinasesto control cell motility, invasion and survival.FAK1 hasbeen demonstrated to modulate cancer cell proliferation,survival, migration and angiogenesis.
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