Abstract
Abstract The 2-naphthol derivative 2, which corresponds to the aromatic moiety of the enediyne antibiotic N1999A2, was found to degrade protein under irradiation with long-wavelength UV light in the absence of any additives. Structure–activity relationship studies of 2 indicated that 3, in which the primary hydroxyl group at the C5 position of 2 is modified with a t-butyldiphenylsilyl group, has strong protein photodegradation ability. Furthermore, the theranostic molecule 5 was designed and synthesized. Compound 5 comprises a disulfide moiety linked to the hydroxyl group at the C2 position of 3 and to the fluorescent molecule dicyanomethylene-4H-pyran (DCM) chromophore derivative 6. The disulfide moiety is cleaved in the presence of glutathione (GSH), 5 showed significantly reduced photolytic activity and fluorescence compared to 3 and 6, but produced 3 and 6 when reacted with GSH. 5 showed selective fluorescence and photocytotoxicity against cancer cells that highly express GSH.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
