Abstract
Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behavioral screening is inefficient in most model organisms. But, automated technologies are enabling a new phase of discovery-based research in central nervous system (CNS) pharmacology. Researchers are using large-scale behavior-based chemical screens in zebrafish to discover compounds with new structures, targets, and functions. These compounds are powerful tools for understanding CNS signaling pathways. Substantial differences between human and zebrafish biology will make it difficult to translate these discoveries to clinical medicine. However, given the molecular genetic similarities between humans and zebrafish, it is likely that some of these compounds will have translational utility. We predict that the greatest new successes in CNS drug discovery will leverage many model systems, including in vitro assays, cells, rodents, and zebrafish.
Highlights
At a recent course on neurotherapeutic drug discovery (sponsored by the National Institutes of Health) the keynote speaker joked that if he were trying to be rational, he would not be trying to discover neuroactive drugs
At a recent course on neurotherapeutic drug discovery the keynote speaker joked that if he were trying to be rational, he would not be trying to discover neuroactive drugs
Someday, when researchers understand the biochemical mechanisms of psychiatric disease, it may be possible to discover neuroactive drugs based on rational therapeutic hypotheses
Summary
At a recent course on neurotherapeutic drug discovery (sponsored by the National Institutes of Health) the keynote speaker joked that if he were trying to be rational, he would not be trying to discover neuroactive drugs. Researchers are using large-scale behavior-based chemical screens in zebrafish to discover compounds with new structures, targets, and functions. These drugs, including the first modern anxiolytics, antipsychotics and antidepressants, were discovered based on unexpected behavioral phenotypes.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
