Abstract
Objective. The study aimed to assess the dynamics of the systemic immune response in patients during mesotherapy with hyaluronic acid (HA).Materials and methods. The observation group included 26 women who received the first-time mesocorrection with drugs based on hyaluronic acid (HA). Injections of low molecular weight HA were carried out according to standard methods in a course of 5 procedures with an interval of 14 days. The parameters of the innate and adaptive immune response were studied before and two weeks after the end of the course. The skin condition was assessed by dermatoscopy (Aramo Smart Lite 300, Southern Korea).Results. The clinical effect of the course of procedures was reflected in the subjective improvement in the appearance. The improvement was confirmed by hardware analysis, which recorded an increase in hydration, a smoothing of the skin relief, and a decrease in the depth of wrinkles. At the end of the course, redistribution of lymphocyte populations towards natural killer cells and B-lymphocytes was revealed with a decrease in the total number of T cells. The antibody production of immunoglobulins of classes M and G was increased, the serum content of Ig A and IgE was reduced, the number of both T-effectors and T-lymphocytes with immunosuppressive activity increased. Changes in the neutrophil system were characterized by the inhibition of the production of reactive oxygen intermediates; the dynamics of the expression of Toll-like receptors by monocytes was ambiguous.Conclusion. The results of the study confirmed the active involvement of the factors of innate and adaptive systemic response in the cosmetic effect, which manifested itself immediately after mesotherapy as systemic dysregulatory immune changes.
Highlights
The study aimed to assess the dynamics of the systemic immune response in patients during mesotherapy with hyaluronic acid (HA)
Injections of low molecular weight HA were carried out according to standard methods in a course of 5 procedures with an interval of 14 days
The results of the study confirmed the active involvement of the factors of innate and adaptive systemic response in the cosmetic effect, which manifested itself immediately after mesotherapy as systemic dysregulatory immune changes
Summary
Цель: оценить динамику системного иммунного реагирования пациентов при мезотерапии гиалуроновой кислотой (ГК). До начала проведения и через две недели по окончании курса были исследованы параметры врождённого и адаптивного иммунного ответа. Результаты: клинический эффект курса процедур отразился в субъективном улучшении внешнего вида и подтвержден аппаратным анализом, зафиксировавшем повышение увлажненности, выравнивание рельефа и уменьшение глубины морщин. По окончании курса процедур по сравнению с исходными данными выявлено перераспределение популяций лимфоцитов в сторону натуральных киллеров и В-лимфоцитов при снижении общего числа Т-клеток. При этом усилена антителопродукция иммуноглобулинов классов М и G и снижено сывороточное содержания Ig А и IgE, увеличено количество как Т-эффекторов, так и Т-лимфоцитов с иммуносупрессивной активностью. Заключение: результаты исследования подтверждают активное вовлечение в реализуемый косметический эффект факторов врождённого и адаптивного системного ответа, что сразу по окончании процедур мезотерапии ГК проявляется в системных дисрегуляторных иммунных изменениях
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