Abstract
Among NRTIs, d4T is one of the most potent inhibitors of mitochondrial DNA polymerase gamma, and its use has been associated with both elevated serum lactate levels and the development of lipoatrophy. A key question is whether, once these conditions develop, replacing d4T with another NRTI can help to reverse them. Patients who had received d4T for at least 6 months as part of a successful …
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