Abstract
Endometriosis is defined as a hormone-dependent benign inflammatory disease of the female reproductive system...
Highlights
This article will furnish the readers with up-to-date knowledge regarding the biomarkers, infertility, pregnancy, and carcinoma with the ailment and shed light on the management of the disease
Endometriosis is defined as a hormone-dependent benign inflammatory disease of the female reproductive system characterized by the implantation and growth of lesions formed by endometrial stromal and epithelial cells present outside the uterine cavity, mainly in the peritoneum associated with abdominal viscera [1,2,3]
This study showed that the gradual expensive diagnosis economic burden associated with endometriosis espied in the referral centers is high and is similar to other chronic diseases [23]
Summary
Endometriosis is defined as a hormone-dependent benign inflammatory disease of the female reproductive system characterized by the implantation and growth of lesions formed by endometrial stromal and epithelial cells present outside the uterine cavity, mainly in the peritoneum associated with abdominal viscera [1,2,3]. These comprise various elements like transcription factors, hormones, growth factors, cytokine/chemokine’s signaling, cell cycle regulation, adhesion, the immune system, and proteases, including genes associated with steroidogenesis, implantation, and placental development could be affected [48]. Endometriosis is a benign inflammatory disease the molecular and cellular features work in a similar manner like; malignancy occurs, including increased cell proliferation, re-expression of the pluripotent transcription factor OCT4 [95], epithelial-tomesenchymal transition [96] acquisition of migratory phenotype [95,97] development of distant foci, cell adhesion, invasion [98] angiogenesis, and at times, treatment resistance [99].
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