DISBALANCE OF BIORADICAL PROCESSES AS THE MAIN CAUSE OF DISORGANIZATION OF CONNECTIVE TISSUE STRUCTURES IN EXPERIMENTAL PERIODONTITIS

Abstract

Abstract: Relevance. The features of the dynamics of free radical processes, as well as the metabolism of collagen structures of the connective tissue matrix against the background of periodontitis will reveal deeper pathogenetic mechanisms and application points for the introduction of new therapeutic and diagnostic technologies into practice. The purpose of the study. Assessment and establishment of interrelations between the intensity of bio-radical processes and collagen metabolism in dynamics in experimental periodontitis. Materials and methods. The study used 45 white nonlinear rats, on which the model of periodontitis proposed by Shkolnaya K. D., Atrushkevich V.G. (Patent RU No. 2625295 dated 12.07.2017) was reproduced. The total activity of free radical oxidation and the antioxidant potential of the body were monitored by the biochemiluminescence method, and markers of collagen metabolism were recorded. Results. The study revealed a sharp predominance of oxidative processes and the inability of the antioxidant potential to suppress free radical peroxidation, as evidenced by the persistently high levels of total luminescence intensity and biohemiluminescence light sum that persist throughout the experiment, despite dynamic changes. Reactive oxygen species in conditions of progressive chronic inflammation have a damaging effect on collagen fibers, which means they lead to the inevitable destruction of the periodontal complex, which is expressed in the growth of CO and PSO. In addition, there is a significant direct correlation between the dynamics of the intensity of free radical oxidation and the indicators of collagen metabolism. Conclusion. Thus, oxidative stress, progressing against the background of periodontitis, leads to disorganization of connective tissue structures of the periodontal. In turn, the study confirms the validity of the use of markers of the intensity of free radical oxidation and collagen metabolism to diagnose the severity of the disease and prognosis, as well as the need for the use of antioxidant drugs as part of complex therapy.