Disaharidase deficiency – is one of the causes of functional disorders of intestine.

Abstract

The aim of the study was to show the importance of intestinal carbohydrase (glucoamylase, maltase, sucrase and lactase) in the etiology and pathogenesis of functional bowel diseases. Material and methods. It was examined 74 patients with FBD in age from 18 to 50 years (36 men and 38 women.). According to Rome IV criteria (2016) 21 had irritable bowel syndrome (IBS) with predominance of diarrhea , 33 functional diarrhea, 6 - IBS with predominant constipation , 4 functional constipation and 10 IBS mixed type. Karbohidrase activity in mucosa of the small intestine was investigated by the method of Dahlquist modification Trinder in duodenal biopsies obtained during esophagogastroduodenoscopy. Results. Lactase deficiency identified in 87.8%, maltasa - 48.6 percent, saharasia - 51,3%, the lack of glucoamylase - in 85.1% of patients. The activity of all investigated enzymes was reduced in 23 (31.1%) patients with functional bowel disease. Normal activity of enzymes have 4 (5,4%) patients. Conclusion. In 70 of 74 patients with functional bowel disease violations of the chair, abdominal pain and flatulence due to the decrease in the activity of carbohydrase of mucosa. The reason of disaccharidase deficiency may be due to the acute intestinal infections, antibiotic and medicine (NSAIDs) treatment.