Abstract
Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p < 0.05). The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not.
Highlights
Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS)
The EDSS, Guy Neurological Disability Scale (GNDS), and Functional Assessment of Multiple Sclerosis (FAMS) scores were higher among patients with fatigue (Table 1)
EDSS score, smoking, maximal expiratory pressure, peak expiratory flow, GNDS, and FAMS scores were evaluated by multivariate analysis considering the presence of fatigue as the dependent variable (Table 4)
Summary
Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p < 0.05). Conclusions: The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not. Métodos: Foram comparados marcadores inflamatórios, pressões respiratórias, incapacidade e qualidade de vida em 39 pacientes com EMRR com e sem fadiga.
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