Direct‐Type Aldol Reactions of Fluorenylidene‐Protected/Activated Glycine Esters with Aldehydes for the Synthesis of β‐Hydroxy‐α‐amino Acid Derivatives

Abstract

Two birds with one stone: Magnesium-base-catalyzed highly diastereoselective direct-type aldol reaction of glycine Schiff base bearing a fluorenylidene moiety as a protecting and activating group was developed. The desired reactions proceeded smoothly at low temperature, and the aldol products were obtained in high yield with high diastereoselectivity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.