Abstract
A comparison of colorectal cancer and normal cells from 103 patients identifies dozens of genes that are differently expressed in tumour cells as a result of altered regulation of transcription. See Letter p.87 This paper presents a comprehensive overview of the transcriptome alterations and changes in the regulatory landscape associated with colorectal cancer tumorigenesis. Using RNA sequencing of 103 matched tumour and normal colon mucosa samples from patients with colorectal cancer, and investigating allele-specific expression, the authors show that germline genotypes remain important determinants of allelic gene expression in tumours and identify 71 genes with excess of somatic cis-regulatory effects in colorectal cancer, suggesting a cancer driver role. New expression quantitative trait loci (eQTLs) are identified, 36% of which are exclusive to colorectal cancer. Additional evidence indicates that tumour-specific eQTL genes constitute germline-derived cancer regulatory drivers.
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