Abstract
How cells ensure that productive transcription from divergent promoters is limited to the downstream protein-coding region is an important question in the transcription field. A recent study in Nature proposed an answer by revealing that the upstream antisense transcripts undergo early termination through the polyadenylation signal-dependent pathway, and the downstream sense transcripts are protected from premature cleavage by U1 small nuclear ribonucleoprotein (snRNP).
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