Abstract
AbstractThe first synthesis of both enantiomers of 6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline‐1‐carboxylic acid was accomplished through dynamic kinetic resolution in procedures based on CAL‐B‐ or subtilisin Carlsberg‐catalysed enantioselective hydrolysis of the corresponding ethyl esters in aqueous NH4OAc buffer at pH 8.5. The products were obtained with high enantiopurity (92–93 % ee) in good yields (85–92 %). (R)‐1,2,3,4‐Tetrahydroisoquinoline‐1‐carboxylic acid was obtained with high enantiopurity (98 % ee) and in good yield (85 %) in a CAL‐B‐catalysed process, under similar conditions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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