Abstract
Polycomb-group (PcG) complex 1 (also designated as Polycomb repressive complex 1) and Hoxb4/Hoxa9 are well-known cell-intrinsic factors regulating the activity of hematopoietic stem cells (HSCs). Although these factors act as transcriptional regulators, we previously uncovered that either of these factors also acts as an E3 ubiquitin ligase for Geminin to regulate expression level of the protein. Geminin negatively regulates a DNA replication licensing factor, Cdt1, and a subunit of chromatin remodeling factor, Brahma or Brg1.
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