Abstract
Abstract: A facile methodology has been developed to build carbon nitrogen double bond from ketones promoted by the hydroxyl groups in β-phenol hydroxy ketone. It is noteworthy that the halogenated β-phenol hydroxy ketone can chemoselectively react with the amine to afford halogenated phenol imine. It is suitable for certain natural products and also suitable for water-based heteroamines. The method possesses low toxicity and is widely applicable. This strategy is usually used to obtain moderate to good yields of aromatic amine Schiff base.
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