Abstract
The C-N bond of carboxamides is extremely stable under most conditions. The present study reveals an unconventional approach to the transamidation of primary amides using DCID as C-N bond activator. DCID alone mediates the reactions and no additional metal catalyst is required. The method exhibits broad scope and secondary and tertiary amide synthesized in good yield. The chemical structures of the intermediate 3 and all-synthesized compounds were confirmed by comparison of melting point with literature and NMR spectra.
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