Direct synthesis of α-Ketothioamides from in situ generated α-Keto sulfines and amines via the thioamide bond construction

Abstract

We have developed a practical, general protocol from readily available phenacyl sulfoxides bearing tetrazoles with amines to access a broad scope of α-ketothioamides under mild conditions. The reaction has good substrate applicability, and provides an efficient, green and convenient method for the preparation of α-ketothioamide compounds under metal-, oxidant- and catalyst-free conditions.