Abstract
A new Prostaglandin D2 (PGD2) was investigated for its effect on growth hormone (GH) secretion from rat anterior pituitary in vitro and in vivo. PGD2 significantly suppressed the secretion of rat GH and the suppressive effect induced by PGD2 was dose-dependent when rat anterior pituitaries were incubated for 4 hours in vitro with PGD2 at a concentration of more than 100 μg/ml. Slightly more GH was contained in the anterior pituitaries of the PGD2-stimulated group than in those of the control group, suggesting that PGD2 may suppress not the synthesis, but the release of GH. In contrast, intravenously administered PGD2 did not affect serum GH levels in vivo. These results suggest that the suppressive effect on GH secretion is due to direct action of PGD2 on the pituitary gland.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asia-Oceania journal of obstetrics and gynaecology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
