Abstract
Molecular lanthanoid complexes are highly valuable building blocks for a number of important technological applications, e.g. as contrast agents in magnetic resonance imaging (MRI) or as luminescent probes for bioassays. For the next generation of advanced applications based on molecular species, heterooligonuclear lanthanoid complexes with well-defined chemical and structural compositions are required. The great kinetic lability of trivalent lanthanoids so far prevents the realization of such molecular architectures with a universally applicable methodology. Here, we have developed functionalized molecular lanthanoid cryptates as monomeric building blocks which can be directly linked by standard solid-phase peptide synthesis to yield sequence-specific heterooligonuclear lanthanoid complexes. These molecular materials enable unique applications such as the generation of molecular codes with very convenient luminescence read-out.
Highlights
Molecular lanthanoid complexes are highly valuable building blocks for a number of important technological applications, e.g. as contrast agents in magnetic resonance imaging (MRI) or as luminescent probes for bioassays
While the direct solid-phase peptide synthesis (SPPS) approach has proven viable for certain transition metal building blocks in the past, the important class of molecular lanthanoid complexes has so far not been amenable to this attractive strategy
As a prototypical example of the potential of this powerful approach, we show in a proof-ofconcept study that molecular materials can be realized that can be encoded by a specific lanthanoid luminescence response
Summary
Molecular lanthanoid complexes are highly valuable building blocks for a number of important technological applications, e.g. as contrast agents in magnetic resonance imaging (MRI) or as luminescent probes for bioassays. One of the great strengths of organic chemistry is its ability to prepare covalently connected oligo- or polymeric structures in a controlled, sequence-specific manner from a set of similar yet different monomeric building blocks, such as amino acids, nucleotides, monosaccharides, etc.
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