Direct Sequential C3 and C1 Arylation Reaction of Imidazo[1,5-a]pyridine Catalyzed by a 1,10-Phenanthroline–Palladium Complex

Abstract

Abstract The direct sequential arylation reaction at the C3 and C1 positions of imidazo[1,5-a]pyridines with a variety of aryl iodides catalyzed by [Pd(phen)2](PF6)2 is described. The reaction of unsubstituted imidazo[1,5-a]pyridine with various aryl iodides proceeded selectively at the C3 position to exclusively give the corresponding C3-arylated products. The one-pot double-arylation reaction at the C3 and C1 positions of unsubstituted imidazo[1,5-a]pyridine with different aryl groups was also achieved.