Abstract
PURPOSE: Human normal M-type A1PI occurs in plasma in several isoforms that are molecules with different numbers of sialic acids (isoforms M1, M2, M4, M6) or missing 5 N-terminal amino acids (M7, M8). In addition A1PI concentrates lack the C-terminal amino acid lysine. Less is known about the A1PI isoform pattern in broncheoalveolar lavage solutions. This is mainly because A1PI is found in low concentrations in the range of few μg/ml impeding a direct analysis with IEF. Here we describe a convenient method, relying on commercially available reagents and IEF gels, that enables the A1PI isoform pattern to be revealed in dilute solutions.
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