Abstract
A direct screening technique was devised in which applications of a juvenile hormone analogue (JHA) (RO-20-3600; ENT No. 70357; 6,7-Epoxy-3-methyl-7-ethyl-1-(3,4-[methyl-enedioxy]-(phenoxy)-2- cis/trans-octene), Hoffman-LaRoche) to the food resulted in the death of all the F-1 descendants of mutagenized Drosophila melanogaster males with the exception of those animals which possessed sexlinked mutations affecting the metabolism of JHA. These exceptions would comprise (a), those mutant animals which possess any resistance to the lethal effects of the JHA (JH R mutants) and/or (b), those mutant animals which have a defective JH metabolism and would normally die but are rescued by the exogenous application of JHA (JH − mutants). Approximately 95, 850 mutagenized chromosomes were tested in this screen, 99,6% of which were killed by the JHA. Of the surviving 181 fertile males, 6 were found to be JH R mutants. The statistically significant resistance factors ranged from 1.4X to 21.5X. The analysis of the most resistant mutant strain indicates that it may possibly be a behavioral mutant. The implications of such JH R mutants are discussed in terms of ‘third generation pesticides’.
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