Abstract
Aim. To study the effectiveness of a direct renin inhibitor, aliskiren, in patients with menopausal metabolic syndrome (MMS), and to assess aliskiren effects on blood pressure (BP), carbohydrate and lipid metabolism parameters, microalbuminuria, and arterial stiffness. Material and methods. The study included 23 women with MMS, to whom aliskiren monotherapy (150-300 mg/d) was administered. At baseline and in the end of the study, anthropometry, carbohydrate and lipid metabolism parameters assessment, 24-hour BP monitoring, and arterial stiffness assessment by volume sphygmography were performed. Results. By the end of the study, most parameters of circadian BP profile significantly decreased. Target levels of systolic and diastolic BP were achieved in 80 % of the patients. There was a significant reduction in postprandial glucose levels. According to the volume sphygmography results, a decrease in arterial stiffness was accompanied by a significant reduction in pulse wave velocity and augmentation index, with normalization of the former parameter. Conclusion. Aliskiren therapy demonstrated not only high antihypertensive effectiveness in MMS patients, but also a reduction in postprandial glucose levels and arterial stiffness.
Highlights
ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° Π²ΡΡΠΎΠΊΠ°Ρ Π°Π½ΡΠΈΠ³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠ²Π½Π°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°Π»ΠΈΡΠΊΠΈΡΠ΅Π½Π° Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΠΠΠ‘, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠ°ΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΡΡΠΏΡΠ°Π½Π΄ΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π³Π»ΡΠΊΠΎΠ·Ρ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΈΠ³ΠΈΠ΄Π½ΠΎΡΡΠΈ ΠΌΠ°Π³ΠΈΡΡΡΠ°Π»ΡΠ½ΡΡ Π°ΡΡΠ΅ΡΠΈΠΉ.
Π§ΡΠΎ, Π²ΠΎ-ΠΏΠ΅ΡΠ²ΡΡ , Ρ ΠΎΡΡ ΠΈ Π½Π΅ΡΡΠ½Ρ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Π² Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΡΠ΅Π½ΠΈΠ½Π° [9,10], Π°Π»ΠΈΡΠΊΠΈΡΠ΅Π½ ΠΏΠΎΠΊΠ°Π·Π°Π» ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠΈ Π‘ΠΠ ΠΈ ΠΠΠ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ Π² ΠΌΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² ΡΠ°Π·ΠΎΠ²ΠΎΠΉ ΡΡΡΠΎΡΠ½ΠΎΠΉ Π΄ΠΎΠ·Π΅.
ΠΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠΠ’ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠΆ: Π³ΠΈΠ΄ΡΠΎΡ Π»ΠΎΡΡΠΈΠ°Π·ΠΈΠ΄ (ΠΠ₯Π’Π), Π°ΠΌΠ»ΠΎΠ΄ΠΈΠΏΠΈΠ½/ΠΠ₯Π’Π 10/25 ΠΌΠ³, ΠΈΡΠ±Π΅ΡΠ°ΡΡΠ°Π½/ΠΠ₯Π’Π 300/25 ΠΌΠ³ ΠΈ Π°Π»ΠΈΡΠΊΠΈΡΠ΅Π½/ΠΠ₯Π’Π 300/25 ΠΌΠ³) Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΠΠ’ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠΠ’, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° ΠΠ Π, ΠΠ ΠΈ Π, ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ.
Summary
ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° Π²ΡΡΠΎΠΊΠ°Ρ Π°Π½ΡΠΈΠ³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠ²Π½Π°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°Π»ΠΈΡΠΊΠΈΡΠ΅Π½Π° Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΠΠΠ‘, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠ°ΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΡΡΠΏΡΠ°Π½Π΄ΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π³Π»ΡΠΊΠΎΠ·Ρ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΈΠ³ΠΈΠ΄Π½ΠΎΡΡΠΈ ΠΌΠ°Π³ΠΈΡΡΡΠ°Π»ΡΠ½ΡΡ Π°ΡΡΠ΅ΡΠΈΠΉ. Π§ΡΠΎ, Π²ΠΎ-ΠΏΠ΅ΡΠ²ΡΡ , Ρ ΠΎΡΡ ΠΈ Π½Π΅ΡΡΠ½Ρ Π½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Π² Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ ΡΠ΅Π½ΠΈΠ½Π° [9,10], Π°Π»ΠΈΡΠΊΠΈΡΠ΅Π½ ΠΏΠΎΠΊΠ°Π·Π°Π» ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠΈ Π‘ΠΠ ΠΈ ΠΠΠ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠ Π² ΠΌΠΎΠ½ΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² ΡΠ°Π·ΠΎΠ²ΠΎΠΉ ΡΡΡΠΎΡΠ½ΠΎΠΉ Π΄ΠΎΠ·Π΅. ΠΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠΠ’ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΠΆ: Π³ΠΈΠ΄ΡΠΎΡ Π»ΠΎΡΡΠΈΠ°Π·ΠΈΠ΄ (ΠΠ₯Π’Π), Π°ΠΌΠ»ΠΎΠ΄ΠΈΠΏΠΈΠ½/ΠΠ₯Π’Π 10/25 ΠΌΠ³, ΠΈΡΠ±Π΅ΡΠ°ΡΡΠ°Π½/ΠΠ₯Π’Π 300/25 ΠΌΠ³ ΠΈ Π°Π»ΠΈΡΠΊΠΈΡΠ΅Π½/ΠΠ₯Π’Π 300/25 ΠΌΠ³) Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΠΠ’ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠΠ’, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° ΠΠ Π, ΠΠ ΠΈ Π, ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ.
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