Abstract
Loss of beta-cell mass is the most important factor for the pathogenesis of type 1 and type 2 diabetes. Our previous results showed that inhibition of the calcium-calmodulin dependent phosphatase calcineurin by the structurally distinct immunosuppressant drugs cyclosporin A and tacrolimus decreased insulin gene transcription and both drugs stimulated the catalytic activity of the mitogen-activated protein kinase kinase kinase 12 (DLK Dual Leucine zipper kinase) and induced beta-cell apoptosis. In the present study, the regulation of DLK by calcineurin was investigated.
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