Direct reconstruction of tissue temperature fields during thermal therapy by dynamic response matching and steady-state correction

Abstract

In the field of oncology thermotherapy technology, online and real-time reconstruction of biological tissue temperature field is a fundamental work with important practical needs. In this paper, we proposed a new method for direct reconstruction of biological tissue temperature field by dynamic response feature matching and steady-state correction. Based on the bioheat transfer equation, the step response model of tissue temperature field during thermal therapy is established, and the dynamic response eigenvectors of biological tissue temperature and the steady-state gain of temperature response are determined offline. According to the optimal matching principle between the temperature dynamic response of the observation point and the internal space point of tissue, the optimal matching matrix of the dynamic response features between the observation point temperature and the internal temperature field of tissue is determined with the use of the dynamic response eigenvectors. Further, through the weighted synthesis of observation point temperature response by using the optimal matching matrix of dynamic response features, the tissue transient temperature field pre-estimation model is established. Finally, by correcting the tissue temperature field pre-estimation model with steady-state gain correction factor, the direct reconstruction scheme of temperature field based on dynamic response feature matching and steady-state gain correction is established. In this work, the non-destructive reconstruction of the internal temperature field of biological tissues during laser-induced thermal therapy is achieved based on the above direct reconstruction scheme. Numerical simulation experiments are performed to investigated the effects of pre-estimation time domain, the number of measurement points, laser irradiation form and measurement error on the temperature field reconstruction results.