Abstract
The feasibility of determining cardiac output by the indicator dilution principle, without the need for any calculation or the withdrawal of blood, was studied in 15 patients and 3 dogs. A total of 150 curves were utilized and good agreement found between the “direct” reading obtained from a cardiac output “meter” and the result derived from more conventional indicator dilution calculations. Cardiac outputs were studied with varying heart rates, samplings, and injection sites, and varied from 1 to 16 L. per minute. The advantages of the method lie in its speed, the use of a conventional indicator (indocyanine green), the ease of calibration which is accomplished with only 3 ml. of blood, and the absence of the need for repeated withdrawal of arterial blood samples.
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