Abstract
Small multidrug resistance (SMR) transporters provide an ideal system to study the minimal requirements for active transport across a membrane. EmrE is an E. coli SMR transporter that exports a broad class of polyaromatic cation substrates, thus conferring resistance to drug compounds matching this chemical description. As a secondary active antiporter, EmrE drives the uphill export of each substrate molecule by coupling it to the downhill import of 2 protons across the inner membrane. EmrE is proposed to function via a single-site alternating access model.
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