Abstract
In today's Lancet, the DIRECT investigators report two pivotal papers from the DIRECT (DIabetic REtinopathy Candesartan Trials) study, which randomised 5231 patients with type 1 or type 2 diabetes into daily placebo or 32 mg candesartan, an angiotensin II receptor blocker).1,2 The study recruited from 309 worldwide sites, and followed up patients for 4 years. The investigators report on prevention and progression of diabetic retinopathy in type 1 diabetes (respectively: DIRECT-Prevent 1, n=1421; DIRECT-Protect 1, n=1905),1 and on progression and regression of diabetic retinopathy in type 2 diabetes (DIRECT-Protect 2, n=1905).
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